PhenobarbitalÀÇ ¿ëÃâ¼Óµµ(éÁõóáÜÓø)¸¦ Áõ°¡½ÃÅ°±â À§ÇÏ¿© PVP¿ÍÀÇ °øħ¹°(ÍìöØÚª)À» Çü¼º(û¡à÷)ÇÑ ÈÄ ÀÏÁ¤(ìéïÒ)ÇÑ Ç¥¸éÀû(øúØüîÝ)ÇÏ¿¡¼ÀÇ ¿ëÃâ¼Óµµ(éÁõóáÜÓø)¸¦ ºñ±³°ËÅä(ÝïÎòËþ÷Ð)ÇÏ¿´´Ù. 37?C, 150r.p.m¡¿¿¡¼ÀÇ rate constannt of dissolution, k,´Â phenobarbitalÀÌ 8.75¡¿10?6M/min, 1 : 2 phenobarbital-PVP coprecipiate´Â 5.35¡¿10?5M/minÀ̾úÀ¸¸ç, activation energy of dissolution, Ea´Â phenobarbitalÀÌ ¾à 10,600cal/mole coprecipitate´Â ¾à 5,800cal/molÀ̾ú´Ù. ±×¸®°í X-ray diffraction study¿¡ ÀÇ(ëî)Çϸé Æä³ë¹Ù¸£ºñÅ» ´ÜÀϹ°Áú(Ó¤ìéÚªòõ)À̳ª, PVP¿ÍÀÇ physical mixture¿¡¼´Â Æä³ë¹Ù¸£ºñÅ»ÀÇ °áÁ¤ÇÇÅ©¸¦ ³ªÅ¸³»¾úÀ¸³ª, PVP¿ÍÀÇ °øħ¹°(ÍìöØÚª)ÀÇ °æ¿ì(ÌÑéç)¿¡´Â Æä³ë¹Ù¸£ºñÅ»ÀÇ °áÁ¤ÇÇÅ©¸¦ ÀÎÁö(ìãò±)ÇÒ ¼ö ¾ø¾ú´Ù.
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